Completed illustration intended for 24" x 13.5" poster output.
References
Doudna, J. A., & Charpentier, E. (2014). The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213), 1258096. https://doi.org/10.1126/science.1258096
Jiang, F., & Doudna, J. A. (2017). CRISPR–Cas9 Structures and Mechanisms. Annual Review of Biophysics, 46(1), 505–529. https://doi.org/10.1146/annurev-biophys-062215-010822
Jiang, F., Taylor, D. W., Chen, J. S., Kornfeld, J. E., Zhou, K., Thompson, A. J., Nogales, E., & Doudna, J. A. (2016). Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. Science, 351(6275), 867–871. https://doi.org/10.1126/science.aad8282
Jiang, F., Zhou, K., Ma, L., Gressel, S., & Doudna, J. A. (2015). A Cas9-guide RNA complex preorganized for target DNA recognition. Science, 348(6242), 1477–1481. https://doi.org/10.1126/science.aab1452
Structures obtained from the Protein Data Bank (PDB). Accession codes: 4zt0, 5f9r
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